Near-Death Experiences (NDEs) are profound experiences that frequently occur on the threshold of death. They include phenomena that are difficult if not impossible to reconcile with a materialistic view of the mind, such as enhanced thinking and perceptions while the brain in severely impaired, accurate perceptions from outside the physical body, and encounters with deceased persons not known to have died. Dr. Bruce Greyson has been studying NDEs for almost a half century. In this presentation, he shares some of his most important findings on the nature of life and death, illustrating his research data with captivating examples.  He will discuss challenges in researching NDEs, establishing the reality of NDEs, the most common features of the experience, various models that have been proposed to explain NDEs, and the dramatic transformations that usually follow NDEs. Finally, he will discuss the implications of NDEs for our understanding of mind and brain, for our understanding of the possibility of postmortem survival, and for our understanding of the relationship between biological and spiritual events and what that implies for what it means to be human.