In 1994, the DSM-IV included the new diagnostic category of “Religious or Spiritual Problem” (V code 62.89) in the V code section of “Other Conditions That May Be a Focus of Clinical Attention” which are by definition not mental disorders: “This category can be used when the focus of clinical attention is a religious or spiritual problem.  Examples include distressing experiences that involve loss or questioning of faith, problems associated with conversion to a new faith, or questioning of other spiritual values which may not necessarily be related to an organized church or religious institution.” Both the diagnostic category and its definition were retained in the 2013 DSM-5. In 1992, David Lukoff, Francis Lu, and Robert Turner had submitted a proposal to the DSM-IV Task Force for this new diagnostic category to provide a non-pathological diagnosis for distressing experiences involving religion or spirituality. The goal was to reduce mis-diagnosis of such experiences as psychopathological phenomena consistent with and diagnostic of mental disorders by enlarging the differential diagnosis to include this non-pathological one. By utilizing this diagnostic category, clinicians can provide appropriate religious/spiritual assessment, diagnosis, and treatment planning including possible religious/spiritual interventions consistent with the individual’s and family’s cultural background and identity. A review of the published literature and case vignettes will amplify the significance and use of this diagnostic category.